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Alphadolone acetate is a steroid-class research compound described as having anesthetic and antinociceptive activity. It is supplied as a solid white to off-white powder for biochemical and pharmacological research; follow appropriate handling and storage guidelines.
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Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of *Plasmodium falciparum* heat shock protein 90 (PfHsp90) with a KD of 8.16 μM. It is cytotoxic to KB cells, with an IC50 value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research.
Triterpenoid compound
Inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) (KD = 8.16 μM)
Cytotoxic to KB cells (IC50 = 8.4 μM)
Potential for use in tumor and antimalarial research
Can reduce the ATPase activity of PfHsp90 in a dose-dependent manner (1-5 mM; 4.5 h)
Has an IC50 of 24.93 μM against the P. falciparum FcB1 strain
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This modified peptide reduces T- and R-type voltage-dependent calcium currents in dorsal root ganglion (DRG) neurons. It demonstrates anti-nociceptive effects in a model of AIDS-induced peripheral neuropathy. This action is achieved by preventing enhancement of T- and R-type calcium channel function.
Reduces T- and R-type voltage-dependent calcium currents.
Shows anti-nociceptive effects.
Acts by preventing enhancement of calcium channel function.
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Glutarylcarnitine-d9 (chloride) is the deuterium labeled Glutarylcarnitine chloride. It is a diagnostic metabolite for malonic aciduria and glutaric aciduria type I, which are monitored in most tandem mass spectrometry newborn screening programs. Deuteration, the incorporation of stable heavy isotopes into drug molecules, has gained attention for its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Can be used as a tracer.
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
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MW 254.24 Da, Purity >99%. Antioxidant flavonoid. Anti-inflammatory and antioxidant properties, also able to induce apoptosis. Potent inhibitor of hypoxia-inducible factor 1α (HIF-1α).
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Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively.
Potent and specific peptide antagonist of bradykinin B2 receptor.
IC50 and Ki of 1.07 nM and 0.798 nM respectively for bradykinin B2 receptor.
For research use only.
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Bazedoxifene acetate (CAS 198481-33-3) is a selective estrogen receptor modulator (SERM) targeting estrogen receptors (ER) It is designed to modulate ER activity thereby regulating estrogen-dependent cellular pathways Bazedoxifene acetate exerts its biological activity primarily through tissue-specific agonism and antagonism of ER In in vitro studies Bazedoxifene acetate demonstrates receptor modulation with reported affinities (Ki) of 26 nM for ER and 99 nM for ER Based on these pharmacological properties Bazedoxifene acetate holds research potential in osteoporosis and bone metabolism studies as well as in investigations of hormone-responsive cellular mechanisms and pancreatic cancer
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Bradykinin acetate (CAS 6846-03-3) is a peptide agonist targeting G protein-coupled B1 and B2 receptors It is designed to activate bradykinin receptors thereby modulating inflammatory responses vascular tone and endothelial signaling pathways Bradykinin acetate exerts its biological activity primarily through endothelium-dependent release of nitric oxide and prostacyclin leading to vasodilation Receptor activation also triggers non-vascular smooth muscle contraction increases vascular permeability and mediates pain signaling pathways Based on these pharmacological properties Bradykinin acetate holds research potential in studies of inflammation pain mechanisms and endothelial cell signaling
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Thymopentin acetate is a biologically active peptide secreted primarily by the epithelial cells of the thymic cortex and medulla. It acts as an effective immunomodulatory agent with a short plasma half-life of 30 seconds. It enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs).
Enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs).
Used in research into immunomodulation.
Applied in studies involving the generation of T-cell lineage from human embryonic stem cells (hESCs).
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